Patients with early age-related macular degeneration exhibit signs of macro- and micro-vascular disease and abnormal blood glutathione levels
| Autor: | Doina Gherghel, Anikó Ekárt, Stephanie Mroczkowska, Lu Qin, Sunni R. Patel, Jonathan Gibson |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Pathology Blood Pressure Pilot Projects medicine.disease_cause Carotid Intima-Media Thickness Gastroenterology Macular Degeneration Cellular and Molecular Neuroscience chemistry.chemical_compound Vascular Stiffness Retinal Diseases Internal medicine medicine Humans Triglycerides Cholesterol business.industry Vascular disease Cholesterol HDL Retinal Vessels Retinal Cholesterol LDL Middle Aged Macular degeneration medicine.disease Glutathione Sensory Systems Oxidative Stress Ophthalmology Blood pressure chemistry Cardiovascular Diseases Circulatory system Arterial stiffness Female business Oxidative stress |
| Zdroj: | Graefe's Archive for Clinical and Experimental Ophthalmology. 252:23-30 |
| ISSN: | 1435-702X 0721-832X |
| DOI: | 10.1007/s00417-013-2418-0 |
| Popis: | Background: This pilot study aimed to investigate systemic and retinal vascular function and their relationship to circulatory markers of cardiovascular risk in early age-related macular degeneration (AMD) patients without any already diagnosed systemic vascular pathologies. Methods: Fourteen patients diagnosed with early AMD and 14 age- and gender-matched healthy controls underwent blood pressure, carotid intima-media thickness (C-IMT) and peripheral arterial stiffness measurements. Retinal vascular reactivity was assessed by means of dynamic retinal vessel analysis (DVA) using a modified protocol. Blood analyses were conducted for glutathione levels and plasma levels of total cholesterol (CHOL), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG). Results: The AMD patients showed significantly greater C-IMT (p = 0.029) and augmentation index (AIx) (p = 0.042) than the age-matched controls. In addition, they demonstrated a shallower retinal arterial dilation slope (Slope AD) (p = 0.005) and a longer retinal venous reaction time (RT) to flickering light (p = 0.026). Blood analyses also revealed that AMD patients exhibited higher oxidized glutathione (GSSG) (p = 0.024), lower redox index (p = 0.043) and higher LDL-C (p = 0.033) levels than the controls. Venous RT parameter correlated positively with blood GSSG levels (r = 0.58, p = 0.038) in AMD subjects, but not in the controls (p > 0.05). Conclusions: Patients diagnosed with early AMD exhibit signs of systemic and retinal vascular alterations that correlated with known risk markers for future cardiovascular morbidity. © 2013 Springer-Verlag Berlin Heidelberg. |
| Databáze: | OpenAIRE |
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