Specific probiotics and virological findings in symptomatic conscripts attending military service in Finland

Autor: Merja Roivainen, Anne Pitkäranta, Liang He, Maija Lappalainen, Riitta Korpela, Simo Siitonen, Mika J. Mäkelä, Mervi Närkiö, Liisa Lehtoranta, Kim Kalima
Rok vydání: 2014
Předmět:
Rhinovirus
viruses
Respiratory virus
Probiotic
medicine.disease_cause
0302 clinical medicine
Nasopharynx
030212 general & internal medicine
Respiratory Tract Infections
Finland
hMPV
human metapneumovirus
Bifidobacterium
0303 health sciences
biology
Respiratory tract infections
Human bocavirus
Common cold
B.
bifidobacterium
3. Good health
Bifidobacterium animalis
RV
human rhinovirus
Military Personnel
Infectious Diseases
Seasons
Adult
medicine.medical_specialty
Adolescent
RTI
respiratory tract infection
EV
human enterovirus
Article
Young Adult
03 medical and health sciences
Lactobacillus rhamnosus
HBoV
human bocavirus
Virology
Internal medicine
Conscript
medicine
Humans
L.
lactobacillus
030304 developmental biology
AdV
adenovirus
Probiotics
biology.organism_classification
medicine.disease
PIV
parainfluenza virus
Case-Control Studies
Immunology
RSV
respiratory syncytial virus
Zdroj: Journal of Clinical Virology
ISSN: 1386-6532
DOI: 10.1016/j.jcv.2014.03.021
Popis: Background Viral upper respiratory tract infections occur frequently among conscripts. Probiotics have reduced viral infections in children attending day care. Limited data are available on the effects of probiotics on the nasopharyngeal presence of respiratory viruses. Objectives To assess, whether probiotics could decrease nasopharyngeal occurrence of respiratory viruses in Finnish conscripts. Study design In a randomized, double-blind, placebo-controlled 90- and 150-day intervention study, 239 nasopharyngeal swab samples were collected from 192 symptomatic conscripts receiving daily chewable probiotic tablet containing Lactobacillus rhamnosus GG and Bifidobacterium animalis ssp. lactis BB-12 (46.9%) or control tablet (53.1%) on visits to a garrison's health care center due to symptoms of infection. The presence of respiratory viruses was tested by PCR-methods, and viral findings were compared between the intervention groups. Results 184 (76.9%) nasopharyngeal samples were positive for at least one respiratory virus. Picornaviruses were the most common viruses and were detected in 155 (84.2%) of samples. Of these, 143 (92.3%) were rhinovirus-positive and 20 (12.9%) were enterovirus-positive. The control group had 83 (64%) and the probiotic group 72 (66%) picornavirus infections ( p = 0.79). Monthly distribution of picornaviruses showed that there were less picornavirus findings after 3 months in the probiotic group than in the control group ( p = 0.0069). However, probiotics did not reduce picornavirus occurrence in other months. Conclusions Overall, probiotics did not reduce viral occurrence in symptomatic conscripts. However, probiotics decreased the presence of picornaviruses after 3 months, which may imply that probiotics play a role against viruses causing common cold. Further investigations are necessary to clarify the mechanisms involved in order to target specific probiotics on specific respiratory viruses.
Databáze: OpenAIRE
Externí odkaz: