Determinants of telomere length across human tissues
| Autor: | Tsung Po Lai, Chenan Zhang, François Aguet, Justin Shinkle, Dayana A. Delgado, Brandon L. Pierce, Lin Chen, Meritxell Oliva, Jennifer A. Doherty, Kristin G. Ardlie, Sarah Kim-Hellmuth, Meytal Chernoff, Kathryn Demanelis, Eduardo Ramirez, Abraham Aviv, Hannah Lin, Habibul Ahsan, Lin Tong, Farzana Jasmine, Mekala Sabarinathan, Barbara E. Stranger, Muhammad G. Kibriya |
|---|---|
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Science |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.aaz6876 |
| Popis: | Telomere shortening is a hallmark of aging. Telomere length (TL) in blood cells has been studied extensively as a biomarker of human aging and disease; however, little is known regarding variability in TL in nonblood, disease-relevant tissue types. Here, we characterize variability in TLs from 6391 tissue samples, representing >20 tissue types and 952 individuals from the Genotype-Tissue Expression (GTEx) project. We describe differences across tissue types, positive correlation among tissue types, and associations with age and ancestry. We show that genetic variation affects TL in multiple tissue types and that TL may mediate the effect of age on gene expression. Our results provide the foundational knowledge regarding TL in healthy tissues that is needed to interpret epidemiological studies of TL and human health. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|