Diminished and erratic absorption of ergocalciferol in adult cystic fibrosis patients
| Autor: | Robert M Aris, Robert K. Lark, David A. Ontjes, Angelia D Blackwood, Gayle E. Lester, Margaret M Hensler, Bruce W. Hollis |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Vitamin medicine.medical_specialty Malabsorption Adolescent Cystic Fibrosis Administration Oral Medicine (miscellaneous) Cystic fibrosis vitamin D deficiency chemistry.chemical_compound Bone Density Internal medicine Vitamin D and neurology Humans Medicine Vitamin D Exocrine pancreatic insufficiency Nutrition and Dietetics business.industry Lipase Middle Aged Vitamin D Deficiency medicine.disease Micronutrient Ergocalciferol Endocrinology Intestinal Absorption chemistry Area Under Curve Case-Control Studies Ergocalciferols Osteoporosis Exocrine Pancreatic Insufficiency Female business medicine.drug |
| Zdroj: | The American Journal of Clinical Nutrition. 73:602-606 |
| ISSN: | 0002-9165 |
| Popis: | Background: Osteoporosis diminishes the quality of life in adults with cystic fibrosis (CF). Vitamin D deficiency resulting from malabsorption may be a factor in the etiology of low bone mineral density (BMD) in patients with CF. Objective: Absorption of oral ergocalciferol (vitamin D2) and the consequent response of 25-hydroxyvitamin D in 10 adults with CF and exocrine pancreatic insufficiency was compared with that of 10 healthy control subjects. Design: In this pharmacokinetic study, CF patients and control subjects were pair-matched on age, sex, and race. Each subject consumed 2500 � g oral vitamin D2 with a meal. The CF group also took pancreatic enzymes that provided ≥ 80 000 U lipase. Blood samples were obtained at baseline and at 5, 10, 24, 30, and 36 h after vitamin D2 consumption to measure serum vitamin D2 and 25-hydroxyvitamin D concentrations. Results: Vitamin D2 concentrations in all subjects were near zero at baseline. CF patients absorbed less than one-half the amount of oral vitamin D2 that was absorbed by control subjects (P < 0.001). Absorption by the CF patients varied greatly; 2 patients absorbed virtually no vitamin D2. The rise in 25-hydroxyvitamin D in response to vitamin D2 absorption was significantly lower over time in the CF group than in the control group (P = 0.0012). Conclusions: Vitamin D2 absorption was significantly lower in CF patients than in control subjects. These results may help explain the etiology of vitamin D deficiency in CF patients, which may contribute to their low BMD. Am J Clin Nutr 2001;73:602‐6. |
| Databáze: | OpenAIRE |
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