Mismatch repair protein MSH2 expression and prognosis of colorectal cancer patients
| Autor: | M F Fresno, E Barbn, C G Bernardo, Lourdes Sanz, J Aza, J G Noval, J.J. González |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Cancer Research Pathology medicine.medical_specialty Multivariate analysis Colorectal cancer Clinical Biochemistry Gastroenterology Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Proto-Oncogene Proteins Internal medicine Humans Medicine Neoplasm Invasiveness Stage (cooking) Aged Neoplasm Staging Aged 80 and over business.industry Cancer Middle Aged Prognosis medicine.disease digestive system diseases DNA-Binding Proteins Survival Rate MutS Homolog 2 Protein 030104 developmental biology Oncology MSH2 030220 oncology & carcinogenesis Etiology T-stage Immunohistochemistry Female Colorectal Neoplasms business Follow-Up Studies |
| Zdroj: | The International journal of biological markers. 19(3) |
| ISSN: | 1724-6008 |
| Popis: | Introduction and aims The role of genetic factors in the etiology and prognosis of patients with sporadic colorectal cancer is controversial. We have therefore investigated the biological and clinicopathological influence of immunohistochemical MSH2 expression in colorectal cancer. Patients and methods A total of 49 consecutive patients with unselected colorectal cancer operated on in our unit were included in the study. All tumors were resected and tumor specimens were evaluated for MSH2 expression. Clinicopathological data and patient survival were correlated with MSH2 staining. Uni- and multivariate analyses were performed. The minimum follow-up period was five years. Results Curative resection was performed in 34 patients (64.9%), 14 of whom subsequently relapsed. At the end of the overall follow-up 25 (51%) patients had died, 21 of cancer-related causes. Twenty-eight patients (57.1%) were negative for MSH2 staining. Only vascular invasion was significantly correlated with MSH2 expression (lower median values; p=0.04). The overall median survival was 47.9 months (95% CI=27–86.6%). Multivariate analysis of variables in relation to survival showed that T stage (p=0.001), N stage (pConclusions Reduced MSH2 expression is frequent in unselected colorectal cancer patients. Only vascular invasion was correlated with MSH2 expression in this study. Survival was related to TN stage and MSH2 staining. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|