Salimyxins and Enhygrolides: Antibiotic, Sponge-Related Metabolites from the Obligate Marine MyxobacteriumEnhygromyxa salina
| Autor: | Gabriele M. König, Till F. Schäberle, Stephan Felder, Edith Neu, Gabriele Bierbaum, Stefan Kehraus |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Nostoc
Magnetic Resonance Spectroscopy medicine.drug_class Antibiotics Molecular Conformation Gram-Positive Bacteria Benzylidene Compounds Biochemistry Microbiology 4-Butyrolactone Myxobacteria Arthrobacter Enhygromyxa salina Gram-Negative Bacteria medicine Animals Myxococcales Molecular Biology Phylogeny biology Obligate Organic Chemistry biology.organism_classification Anti-Bacterial Agents Porifera Sponge Molecular Medicine Diterpenes Bacteria |
| Zdroj: | ChemBioChem. 14:1363-1371 |
| ISSN: | 1439-4227 |
| DOI: | 10.1002/cbic.201300268 |
| Popis: | Unlike their terrestrial counterparts, marine myxobacteria are hardly investigated for their secondary metabolites. This study describes three new compounds (1-3), named salimyxins and enhygrolides, obtained from the obligate marine myxobacterium Enhygromyxa salina. These are the first natural products obtained from Enhygromyxa species. Their structures were elucidated by spectroscopic analysis, including NMR and CD spectroscopy. Enhygrolides are closely related to the nostoclides, which were initially isolated from a cyanobacterium of the genus Nostoc. The salimyxins, representing structurally most unusual degraded sterols, are close to identical to demethylincisterol from the sponge Homaxinella sp. Salimyxin B and enhygrolide A inhibit the growth of the Gram-positive bacterium Arthrobacter cristallopoietes (MIC salimyxin B, 8 μg mL⁻¹; enhygrolide A, 4 μg mL⁻¹). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text