Animal Models of Sepsis
| Autor: | Sergio L. Zanotti-Cavazzoni, Roy D. Goldfarb |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
business.industry Drug Evaluation Preclinical Hemodynamics Comorbidity General Medicine Critical Care and Intensive Care Medicine medicine.disease Shock Septic Sepsis Clinical trial Disease Models Animal Animal model Drug development Small animal medicine Animals Intensive care medicine business Cecum Ligation Severe sepsis Large animal |
| Zdroj: | Critical Care Clinics. 25:703-719 |
| ISSN: | 0749-0704 |
| DOI: | 10.1016/j.ccc.2009.08.005 |
| Popis: | In this review, we start with a general discussion of relevant factors that can determine the validity of a sepsis animal model. We briefly review some of the currently used animal models of sepsis (small animal models and large animal models). We discuss the clinical relevance of animal models in sepsis research today and address potential reasons for the apparent underperformance of animal models in predicting therapeutic success of novel drugs in clinical trials. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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