Aortic dysfunction by chronic cadmium exposure is linked to multiple metabolic risk factors that converge in anion superoxide production
| Autor: | Miguel Garcia-Gonzalez, Samuel Treviño, Fausto Atonal-Flores, Celeste Santamaria-Juarez, Alfonso Díaz, Victor Enrique Sarmiento-Ortega, Patricia Aguilar-Alonso, Eduardo Brambila, Gustavo Lopez-Lopez |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Physiology 030209 endocrinology & metabolism medicine.disease_cause Nitric Oxide Nitric oxide Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Risk Factors Superoxides Physiology (medical) Internal medicine medicine Animals Endothelial dysfunction Rats Wistar Aorta NADPH oxidase biology Superoxide General Medicine medicine.disease Rats Oxidative Stress Endocrinology Blood pressure chemistry 030220 oncology & carcinogenesis Apocynin Hypertension biology.protein Endothelium Vascular Oxidative stress Cadmium |
| Zdroj: | Archives of physiology and biochemistry. 128(3) |
| ISSN: | 1744-4160 |
| Popis: | Context: The chronic exposure to Cadmium (Cd) constitute an risk to develop hypertension and cardiovascular diseases associated with the increase of oxidative stress.Objective: In this study, we investigate the role of metabolic changes produced by exposure to Cd on the endothelial dysfunction via oxidative stress.Methods: Male Wistar rats were exposed to Cd (32.5-ppm) for 2-months. The zoometry and blood pressure were evaluated, also glucose and lipids profiles in serum and vascular reactivity evaluated in isolated aorta rings.Results: Rats exposed to Cd showed an increase of blood pressure and biochemical parameters similar to metabolic syndrome. Additionally, rats exposed to Cd showed a reduced relaxation in aortic rings, which was reversed after the addition of SOD and apocynin an inhibitor of NADPH.Conclusion: The Cd-exposition induced hypertension and endothelial injury by that modifying the vascular relaxation and develop oxidative stress via NADPH oxidase, superoxide and loss nitric oxide bioavailability. |
| Databáze: | OpenAIRE |
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