Synthesis of Some Thiazolo [3,2-b]-1,2,4-triazole-5(6H)-ones and Their Novel Michael Addition Products with Anti-inflammatory Activities
| Autor: | Birsen Tozkoparan, Mevlüt Ertan, Erdem Yesilada, Göknur Aktay |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Magnetic Resonance Spectroscopy Chemical Phenomena Spectrophotometry Infrared medicine.drug_class Pharmacology Carrageenan Anti-inflammatory Mice chemistry.chemical_compound Indometacin Oral administration Drug Discovery medicine Animals Edema Stomach Ulcer Chemistry Physical Chemistry Stomach Anti-Inflammatory Agents Non-Steroidal 1 2 4-Triazole Biological activity Triazoles Thiazoles medicine.anatomical_structure Toxicity Michael reaction Female medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1616-7066 0004-4172 |
| DOI: | 10.1055/s-0031-1300065 |
| Popis: | In this study, 21 new compounds having 2-methyl-6-benzylidenethiazolo [3,2-b]1,2,4-triazol 5(6H)-one (2-4) and 2-methyl-6- (alpha -aminobenzyl)thiazolo[3,2-b]-1,2,4-triazole-5-ol (2a-4g) structures were synthesized, The structures of the compounds were proved by spectral and elemental analysis. All of the compounds synthesized were tested for their anti-inflammatory activiy and ulcerogenic potential in mice at 10, 20 and 40 mg/kg dose Levels. Compound 4b showed higher anti-inflammatory activity than the analogue derivatives and indometacin (CAS 53-86-1), used as a reference drug, at 10 mg/kg dose Level. Generally, the compounds were found to be more reliable than indometacin since they did not cause any reaction in the stomach. |
| Databáze: | OpenAIRE |
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