T1-Based Synthetic Magnetic Resonance Contrasts Improve Multiple Sclerosis and Focal Epilepsy Imaging at 7 T
| Autor: | Jean-Philippe Ranjeva, Thomas Troalen, Tobias Kober, Axel Bartoli, Aurélien Massire, Virginie Callot, Charlotte Seiler, Gilles Brun, Olivier M. Girard, Pierre Lehmann, Maxime Guye, Fabrice Bartolomei, Jean Pelletier, Bertrand Audoin |
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| Přispěvatelé: | Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - AP-HM] (CEMEREM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)- Hôpital de la Timone [CHU - APHM] (TIMONE), Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM] (CEMEREM), Hôpital de la Timone [CHU - APHM] (TIMONE)-Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Aix Marseille Université (AMU), Assistance Publique - Hôpitaux de Marseille (APHM) |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Magnetic Resonance Spectroscopy genetic structures Lesion Identification Wilcoxon signed-rank test Image quality [SDV]Life Sciences [q-bio] 7 t ultra-high field mri multiple sclerosis 030218 nuclear medicine & medical imaging Lesion [SPI]Engineering Sciences [physics] 03 medical and health sciences Epilepsy 0302 clinical medicine medicine Humans neuroradiology Radiology Nuclear Medicine and imaging ComputingMilieux_MISCELLANEOUS Retrospective Studies medicine.diagnostic_test synthetic mri business.industry Multiple sclerosis Brain Magnetic resonance imaging General Medicine medicine.disease Magnetic Resonance Imaging 3. Good health Multiple comparisons problem epilepsy Epilepsies Partial Radiology medicine.symptom business mp2rage 030217 neurology & neurosurgery |
| Zdroj: | Investigative Radiology Investigative Radiology, Lippincott, Williams & Wilkins, 2021, 56 (2), pp.127-133. ⟨10.1097/RLI.0000000000000718⟩ Investigative Radiology, 2021, 56 (2), pp.127-133. ⟨10.1097/RLI.0000000000000718⟩ |
| ISSN: | 1536-0210 0020-9996 |
| DOI: | 10.1097/rli.0000000000000718 |
| Popis: | Objectives Ultra-high field magnetic resonance imaging (MRI) (>= 7 T) is a unique opportunity to improve the clinical diagnosis of brain pathologies, such as multiple sclerosis or focal epilepsy. However, several shortcomings of 7 T MRI, such as radiofrequency field inhomogeneities, could degrade image quality and hinder radiological interpretation. To address these challenges, an original synthetic MRI method based on T-1 mapping achieved with the magnetization-prepared 2 rapid acquisition gradient echo (MP2RAGE) sequence was developed. The radiological quality of on-demand T-1-based contrasts generated by this technique was evaluated in multiple sclerosis and focal epilepsy imaging at 7 T. Materials and Methods This retrospective study was carried out from October 2017 to September 2019 and included 21 patients with different phenotypes of multiple sclerosis and 35 patients with focal epilepsy who underwent MRI brain examinations using a whole-body investigative 7 T magnetic resonance system. The quality of 2 proposed synthetic contrast images were assessed and compared with conventional images acquired at 7 T using the MP2RAGE sequence by 4 radiologists, evaluating 3 qualitative criteria: signal homogeneity, contrast intensity, and lesion visualization. Statistical analyses were performed on reported quality scores using Wilcoxon rank tests and further multiple comparisons tests. Intraobserver and interobserver reliabilities were calculated as well. Results Radiological quality scores were reported higher for synthetic images when compared with original images, regardless of contrast, pathologies, or raters considered, with significant differences found for all 3 criteria (P < 0.0001, Wilcoxon rank test). None of the 4 radiologists ever rated a synthetic image "markedly worse" than an original image. Synthetic images were rated slightly less satisfying for only 3 epileptic patients, without precluding lesion identification. Conclusion T-1-based synthetic MRI with the MP2RAGE sequence provided on-demand contrasts and high-quality images to the radiologist, facilitating lesion visualization in multiple sclerosis and focal epilepsy, while reducing the magnetic resonance examination total duration by removing an additional sequence. |
| Databáze: | OpenAIRE |
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