Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study
| Autor: | Francesca Locatelli, Nicole Probst-Hensch, Anne-Elie Carsin, Lucia Calciano, Alessandro Marcon, Cecilie Svanes, Simone Accordini, Giancarlo Pesce, Christer Janson, Josep M. Antó, Medea Imboden, Anna Beckmeyer-Borowko, Angelo Corsico, Dirk Keidel, Peter Burney, Deborah Jarvis, Cosetta Minelli |
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| Přispěvatelé: | Bodescot, Myriam, Aging Lungs in European Cohorts - ALEC - - H20202015-05-01 - 2019-04-30 - 633212 - VALID, Università degli studi di Verona = University of Verona (UNIVR), Epidemiology of Allergic and Respiratory Diseases Department [iPlesp] (EPAR), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, Hospital del Mar Medical Research Institute [Barcelone, Espagne] (IMIM), CIBER de Epidemiología y Salud Pública (CIBERESP), Universitat Pompeu Fabra [Barcelona] (UPF), Swiss Tropical and Public Health Institute [Basel], University of Basel (Unibas), Università degli Studi di Pavia = University of Pavia (UNIPV), Uppsala University, University of Bergen (UiB), Haukeland University Hospital, Imperial College London, ALEC has received funding from the European Union’s Horizon 2020 research and innovation programme [Grant Agreement No. 633212]. The co-ordination of the ECRHS was supported by the European Commission (phases 1 and 2) and the Medical Research Council (phase 3). The SAPALDIA cohort was funded by The State Secretariat for Education, Research and Innovation (SERI), Switzerland., European Project: 633212,H2020,H2020-PHC-2014-two-stage,ALEC(2015), University of Verona (UNIVR), Epidemiology of Allergic and Respiratory Diseases Department [Paris] (EPAR), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Pavia, Commission of the European Communities |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Respiratory Medicine and Allergy lcsh:Medicine Ageing Lungs in European Cohorts (ALEC) Study airflow obstruction Rate ratio [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract Cohort Studies Pulmonary Disease Chronic Obstructive 0302 clinical medicine 030212 general & internal medicine lcsh:Science Lungmedicin och allergi COPD Multidisciplinary medicine.diagnostic_test Chronic obstructive pulmonary disease Incidence (epidemiology) Smoking Middle Aged Bronchodilator Agents 3. Good health Europe trend Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) Female Cohort study Adult Spirometry Article 03 medical and health sciences Arbetsmedicin och miljömedicin Sex Factors cohort study medicine Humans tobacco smoking European Community Respiratory Health Survey (ECRHS) Disease burden Asthma business.industry lcsh:R Occupational Health and Environmental Health medicine.disease Risk factors 030228 respiratory system [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie incidence [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract lcsh:Q [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Ageing Lungs in European Cohorts (ALEC) Study airflow obstruction cohort study European Community Respiratory Health Survey (ECRHS) incidence Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) tobacco smoking trend business Demography |
| Zdroj: | Scientific Reports Scientific Reports, 2020, 10 (1), pp.3452. ⟨10.1038/s41598-020-60478-5⟩ Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.3452. ⟨10.1038/s41598-020-60478-5⟩ Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-60478-5⟩ |
| Popis: | Investigating COPD trends may help healthcare providers to forecast future disease burden. We estimated sex- and smoking-specific incidence trends of pre-bronchodilator airflow obstruction (AO) among adults without asthma from 11 European countries within a 20-year follow-up (ECRHS and SAPALDIA cohorts). We also quantified the extent of misclassification in the definition based on pre-bronchodilator spirometry (using post-bronchodilator measurements from a subsample of subjects) and we used this information to estimate the incidence of post-bronchodilator AO (AOpost-BD), which is the primary characteristic of COPD. AO incidence was 4.4 (95% CI: 3.5-5.3) male and 3.8 (3.1-4.6) female cases/1,000/year. Among ever smokers (median pack-years: 20, males; 12, females), AO incidence significantly increased with ageing in men only [incidence rate ratio (IRR), 1-year increase: 1.05 (1.03-1.07)]. A strong exposure-response relationship with smoking was found both in males [IRR, 1-pack-year increase: 1.03 (1.02-1.04)] and females [1.03 (1.02-1.05)]. The positive predictive value of AO for AOpost-BD was 59.1% (52.0-66.2%) in men and 42.6% (35.1-50.1%) in women. AOpost-BD incidence was 2.6 (1.7-3.4) male and 1.6 (1.0-2.2) female cases/1,000/year. AO incidence was considerable in Europe and the sex-specific ageing-related increase among ever smokers was strongly related to cumulative tobacco exposure. AOpost-BD incidence is expected to be half of AO incidence. ALEC has received funding from the European Union’s Horizon 2020 research and innovation programme [Grant Agreement No. 633212]. The co-ordination of the ECRHS was supported by the European Commission (phases 1 and 2) and the Medical Research Council (phase 3). The SAPALDIA cohort was funded by The State Secretariat for Education, Research and Innovation (SERI), Switzerland. The principal investigators and team members of the ECRHS and SAPALDIA studies, and the national funders who supported data collection in the ECRHS and SAPALDIA studies are listed in the appendix available in the Supplementary Information. |
| Databáze: | OpenAIRE |
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