Identification of Three Hidradenitis Suppurativa Phenotypes: Latent Class Analysis of a Cross-Sectional Study
| Autor: | Florence Pouget, C. Viallette, Germaine Gabison, Pierre Wolkenstein, Florence Poli, Jean Revuz, Sylvie Bastuji-Garin, Aurélie Le Thuaut, Florence Canoui-Poitrine |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Cicatrix Hypertrophic Dermatology Severity of Illness Index Biochemistry Young Adult Severity of illness medicine Odds Ratio Humans Hidradenitis suppurativa Breast Obesity Prospective Studies Family history Age of Onset Prospective cohort study Molecular Biology Back Leg business.industry Ear Odds ratio Cell Biology medicine.disease Confidence interval Latent class model Surgery Hidradenitis Suppurativa Cross-Sectional Studies Phenotype Axilla Female Age of onset business |
| Zdroj: | Journal of Investigative Dermatology. 133(6):1506-1511 |
| ISSN: | 0022-202X |
| DOI: | 10.1038/jid.2012.472 |
| Popis: | To identify the underlying subtypes of hidradenitis suppurativa (HS), we performed latent class analysis on prospective clinical data of 618 consecutive patients seen between 2002 and 2010. The median patient age was 31 years (Q1=26; Q3=38), median age at HS onset was 20 years (16–25), and median Sartorius score was 18 (11–19); 34.4% of patients were of Hurley stage II or III. A three-class model showed the best fit. Latent class 1 (LC1) patients (48%) had a high probability of breast and armpit lesions (0.74) and hypertrophic scars (0.41). LC2 patients (26%) had a high probability not only of breast and armpit lesions (0.96) but also of lesions in the ears, chest, back, or legs (0.55); follicular lesions (pilonidal sinus: 0.48; comedones: 0.74); severe acne (0.47); and a family history of HS (0.44). Compared with LC1 patients, LC2 patients were more often male (odds ratio, 4.6; 95% confidence interval, 3–7; P |
| Databáze: | OpenAIRE |
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