Regulation of bovine interleukin-1 receptors
| Autor: | Pei-Wen Yu, Huang-Tsu Chen, K Gosink, Brian J. Nonnecke, Marcus E. Kehrli, Linda A. Schuler, L Mattocks, J.J Rejman, Charles J. Czuprynski |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Immunology Inflammation Biology In Vitro Techniques Dexamethasone Downregulation and upregulation In vivo Internal medicine medicine Leukocytes Animals Receptors Interleukin-1 Type II RNA Messenger Receptor Regulation of gene expression Receptors Interleukin-1 Type I General Veterinary Interleukin Receptors Interleukin-1 Receptor antagonist In vitro Cell biology Endocrinology Gene Expression Regulation Cattle medicine.symptom Inflammation Mediators Interleukin-1 |
| Zdroj: | Veterinary immunology and immunopathology. 63(1-2) |
| ISSN: | 0165-2427 |
| Popis: | Interleukin-1 is a key player in inflammation and the immune response. The interleukin-1 family consists of three ligands (IL-1 alpha, IL-1 beta, and the IL-1 receptor antagonist) and two receptors (IL-1RI and IL-1RII). Previous studies suggest a dynamic relationship among these receptors and ligands that regulates the magnitude and extent of IL-1 mediated activities. Our laboratory has cloned and sequenced the bovine type I and II interleukin-1 receptors, and has begun to investigate their regulation in bovine leukocytes in vitro and in vivo. IL-1RI and IL-1RII mRNA levels were upregulated in vitro by various mediators, including dexamethasone, rBoIL-4, rBoGM-CSF, and rHuTNF alpha. Conversely, IL-1RI mRNA levels were down-regulated by IFN-gamma. An in vivo study indicated that IL-1RII mRNA levels increased earlier than IL-1RI mRNA levels in dexamethasone-treated cattle. These findings suggest that early upregulation of IL-1RII, which is a decoy receptor, may be part of the anti-inflammatory action of glucocorticoids. Our investigations suggest that anti-inflammatory agents increase expression of the biologically inactive IL-1RII, as compared with the biologically active IL-1RI, in bovine leukocytes. |
| Databáze: | OpenAIRE |
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