Disturbed Pubertal Growth in Girls after Acute Leukaemia: a Relative Growth Hormone Insufficiency with Late Presentation
Autor: | C. Moëll |
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Rok vydání: | 2008 |
Předmět: |
medicine.medical_specialty
Adolescent End of therapy Growth hormone Late presentation Internal medicine medicine Humans Child Growth Disorders business.industry Puberty Final height Brain Mean age General Medicine Precursor Cell Lymphoblastic Leukemia-Lymphoma Body Height Growth hormone secretion Endocrinology Child Preschool Growth Hormone Pediatrics Perinatology and Child Health Menarche Female business After treatment |
Zdroj: | Acta Paediatrica. 77:162-166 |
ISSN: | 0803-5253 |
Popis: | Long-term follow-up of growth and development after acute lymphoblastic leukaemia (ALL) in childhood has previously been limited to the prepubertal period. This study describes pubertal growth, final height and the spontaneous secretion of GH in girls treated for ALL, including CNS irradiation with 24 Gy. Ten girls, treated earlier for ALL, experienced the menarche at a mean age of 12.2 years. This is significantly earlier than the mean for Swedish girls. Prepubertal growth was near normal after the end of therapy for leukaemia. Mean final height was -1.7 SD, which is 1.5 SD less than at onset and 1.0 SD less than 1 year after the end of treatment. Thirteen other girls had a blunted spontaneous secretion of GH, several years after treatment for ALL; there was no increase in GH secretion during puberty. These results suggest that girls who have been treated for ALL, including CNS irradiation, have a relative GH insufficiency. This insufficiency becomes obvious only when the girls cannot respond to the increased need for GH during the pubertal spurt. |
Databáze: | OpenAIRE |
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