Venezuelan equine encephalitis virus vaccines induce mucosal IgA responses and protection from airborne infection in BALB/c, but not C3H/HeN mice
| Autor: | Ferdinand Panelo, Mary Kate Hart, William D. Pratt, Mark T. Dertzbaugh, Ralph Tammariello |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
viruses
Air Microbiology Administration Oral Alphavirus Biology Antibodies Viral Vaccines Attenuated medicine.disease_cause complex mixtures Virus BALB/c Encephalitis Virus Venezuelan Equine Mice medicine Animals Immunity Mucosal Aerosols Mice Inbred BALB C Mice Inbred C3H General Veterinary General Immunology and Microbiology Immunogenicity Public Health Environmental and Occupational Health Encephalomyelitis Venezuelan Equine Viral Vaccines biology.organism_classification Virology Titer Infectious Diseases Vaccines Inactivated Immunoglobulin A Secretory Humoral immunity Immunology Venezuelan equine encephalitis virus biology.protein Molecular Medicine Female Antibody |
| Zdroj: | Vaccine. 15:363-369 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/s0264-410x(96)00204-6 |
| Popis: | Immunization with either a live-attenuated (TC-83) or formalin-inactivated (C-84) vaccine for Venezuelan equine encephalitis (VEE) virus protected BALB/c mice from lethal VEE infection acquired subcutaneously or by aerosol. While vaccinated C3H/HeN mice were also protected from parenteral infection, neither vaccine protected these mice from an aerosol infection. The apparent vaccine failures in C3H/HeN mice could not be attributed to deficiencies in virus-neutralizing antibodies in serum, as these responses were typically of equal or higher titer than those observed in protected BALB/c mice before challenge. IgG subclass analysis offered no facile explanation: profiles of IgG2a dominance were observed in C3H/HeN mice given either vaccine and in BALB/c mice given the live-attenuated vaccine, whereas BALB/c antibody responses shifted toward IgG1 dominance after immunization with the killed C-84 vaccine. Data from immunized congenic showed that the H-2 genes from the C3H/He mice were not singularly responsible for the inability of these mice to resist aerosol infection with VEE virus. VEE virus-specific IgA responses were detected more frequently in respiratory and vaginal secretions obtained from the protected BALB/c mice. |
| Databáze: | OpenAIRE |
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