Imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV-1
| Autor: | John G. Catalano, Andrew Spaltenstein, Kristjan S. Gudmundsson, Michael Thomson, Pat Wheelan, Stephen Jenkinson, Boggs Sharon Davis, Angilique Svolto |
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| Rok vydání: | 2009 |
| Předmět: |
Imidazopyridine
Anti-HIV Agents Clinical Biochemistry Pharmaceutical Science HIV Infections Pharmacology Antiviral Agents Biochemistry Chemical synthesis Pharmacokinetics Oral administration In vivo Cell Line Tumor Drug Discovery Humans Molecular Biology biology Chemistry Organic Chemistry HIV biology.organism_classification In vitro Bioavailability Models Chemical Lentivirus HIV-1 Molecular Medicine |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 19:6399-6403 |
| ISSN: | 0960-894X |
| Popis: | Synthesis of several novel imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV are described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in antiviral activity and pharmacokinetics are highlighted. Several compounds with low nanomolar anti-HIV activity and oral bioavailability are described. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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