Altered keratin expression in ichthyosis hystrix Curth-Macklin
| Autor: | M. Muttilainen, Ismo Virtanen, L. Kanerva, Kirsti-Maria Niemi |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty medicine.drug_class Cell Ichthyosis hystrix macromolecular substances Dermatology Vacuole Biology Monoclonal antibody law.invention Pathogenesis 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine law Keratin medicine Humans Child Skin 030304 developmental biology chemistry.chemical_classification 0303 health sciences integumentary system Ichthyosis General Medicine medicine.disease Immunohistochemistry Molecular biology 3. Good health Microscopy Electron medicine.anatomical_structure chemistry Keratins Female Electron microscope |
| Zdroj: | Archives of Dermatological Research. 282:227-233 |
| ISSN: | 1432-069X 0340-3696 |
| DOI: | 10.1007/bf00371641 |
| Popis: | The pathogenesis of a rare form of the ichthyotic diseases, ichthyosis hystrix Curth-Macklin, was investigated by immunohistochemistry and electron microscopy. Monoclonal antibodies (Mabs) against keratins expressed in normal basal cells (PKK2 and KA1), Mabs against keratins only present in normal fetal skin (PKK1), and Mabs against keratins 1, 2, 10, and 11 (KA5 and K8.60) were used. The Mabs reacting with normal basel cells showed an increased reaction with many cell layers. The Mab PKK1 distinctly reacted with the basal cell layer, suggesting an expression of fetal keratins. Electron microscopic study of both normal-looking and involved skin revealed the keratinization disorder characterized by tonofilament shells, perinuclear vacuoles, and binuclear keratinocytes. The results suggest that there is no prematurity of keratinization, but rather a pathological expression of specific keratin genes leading to expression of fetal keratins in this form of ichthyosis hystrix. |
| Databáze: | OpenAIRE |
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