Marine and plant-based n-3 PUFA and atherosclerotic cardiovascular disease

Autor: Anne N. Lasota, Christian Sørensen Bork, Søren Lundbye-Christensen, Stine Krogh Venø, Erik Berg Schmidt
Rok vydání: 2019
Předmět:
Zdroj: Bork, C S, Venø, S K, Lasota, A N, Lundbye-Christensen, S & Schmidt, E B 2020, ' Marine and plant-based n-3 PUFA and atherosclerotic cardiovascular disease ', Proceedings of the Nutrition Society, vol. 79, no. 1, pp. 22-29 . https://doi.org/10.1017/S0029665119000582
ISSN: 1475-2719
0029-6651
Popis: n-3 PUFA may exert favourable effects on several processes that may inhibit the atherosclerotic process. However, the role of n-3 PUFA in lowering the risk of atherosclerotic CVD (ASCVD) has been fiercely debated. In the present paper, we summarise the main findings from previous follow-up studies of intake and studies using adipose tissue as an objective biomarker to investigate exposure to n-3 PUFA in relation to ASCVD risk and discuss some perspectives for further research. The majority of previous studies investigating intake of marine- and plant-based n-3 PUFA have focused on CHD while other ASCVD such as ischaemic stroke and peripheral artery disease have been less studied. However, recent data from Danish Diet, Cancer and Health cohort suggest that marine n-3 PUFA may be inversely associated with risk of myocardial infarction, ischaemic stroke and peripheral arterial disease caused by atherosclerosis. The effect of the plant-derived n-3 PUFA α-linolenic acid on ASCVD is less clear and several gaps in the literature remain to be explored.
Databáze: OpenAIRE
Externí odkaz: