Mining Directional Drug Interaction Effects on Myopathy Using the FAERS Database
| Autor: | Lang Li, Li Shen, Xiaohui Yao, Sara K. Quinney, Pengyue Zhang, Xia Ning, Samuel Lerner, Danai Chasioti |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Apriori algorithm
Drug-Related Side Effects and Adverse Reactions Databases Pharmaceutical Health Informatics computer.software_genre Article 03 medical and health sciences Adverse Event Reporting System 0302 clinical medicine Text mining Health Information Management Pharmacovigilance Medicine Adverse Drug Reaction Reporting Systems Data Mining Humans Rosuvastatin Drug Interactions 030212 general & internal medicine Electrical and Electronic Engineering Myopathy 030304 developmental biology 0303 health sciences Database business.industry Computational Biology Drug interaction Computer Science Applications Informatics medicine.symptom business computer Algorithms medicine.drug |
| Zdroj: | IEEE J Biomed Health Inform |
| ISSN: | 2168-2208 |
| Popis: | Mining high-order drug-drug interaction (DDI) induced adverse drug effects from electronic health record (EHR) databases is an emerging area, and very few studies have explored the relationships between high-order drug combinations. We investigate a novel pharmacovigilance problem for mining directional DDI effects on myopathy using the FDA Adverse Event Reporting System (FAERS) database. Our work provides information on the risk of myopathy associated with adding new drugs on the already prescribed medication, and visualizes the identified directional DDI patterns as user-friendly graphical representation. We utilize the Apriori algorithm to extract frequent drug combinations from the FAERS database. We use odds ratio (OR) to estimate the risk of myopathy associated with directional DDI. We create a tree-structured graph to visualize the findings for easy interpretation. Our method confirmed myopathy association with previously reported HMG-CoA reductase inhibitors like rosuvastatin, fluvastatin, simvastatin and atorvastatin. New, previously unidentified but mechanistically plausible associations with myopathy were also observed, such as the DDI between pamidronate and levofloxacin. Additional top findings are gadolinium-based imaging agents, which however are often used in myopathy diagnosis. Other DDIs with no obvious mechanism are also reported, such as that of sulfamethoxazole with trimethoprim and potassium chloride. This study shows the feasibility to estimate high-order directional DDIs in a fast and accurate manner. The results of the analysis could become a useful tool in the specialists’ hands through an easy-to-understand graphic visualization. |
| Databáze: | OpenAIRE |
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