New amides from seeds of Silybum marianum with potential antioxidant and antidiabetic activities
| Autor: | Jun Xu, Jiao Bai, Fanxing Xu, Cui-Cui Jia, Ningbo Qin, Zhan-Lin Li, Dahong Li, Hui-Ming Hua |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Antioxidant
DPPH medicine.medical_treatment Positive control 01 natural sciences Silybum marianum chemistry.chemical_compound Amide Drug Discovery medicine Humans Hypoglycemic Agents Milk Thistle Glycoside Hydrolase Inhibitors Pharmacology Flavonoids Protein Tyrosine Phosphatase Non-Receptor Type 1 ABTS MILK THISTLE SEED Traditional medicine biology Molecular Structure 010405 organic chemistry alpha-Glucosidases General Medicine Free Radical Scavengers biology.organism_classification Amides 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Biochemistry Seeds |
| Zdroj: | Fitoterapia. 119 |
| ISSN: | 1873-6971 |
| Popis: | Two new amide compounds, mariamides A and B (1-2), were obtained together with fourteen known compounds from the seeds of milk thistle (Silybum marianum). Their structures were established on the basis of extensive 1D and 2D NMR analyses, as well as HR-ESI-MS data. Most of the compounds showed significant antioxidant activities than positive control in ABTS and FRAP assays. However, only amide compounds 1-4 showed moderate DPPH radical scavenging activity and compounds 7 and 16 showed the most potent activity against DPPH. Most of the compounds showed moderate to stronger α-glucosidase inhibitory activities. Nevertheless, only flavonoids showed strong PTP1B inhibitory activities. These results indicate a use of milk thistle seed extracts as promising antioxidant and antidiabetic agents. |
| Databáze: | OpenAIRE |
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