Effects of non-surgical periodontal therapy on clinical and immunological profile and oral colonization of Candida spp in HIV-infected patients with chronic periodontitis
| Autor: | Ana Carolina Fragoso Motta, Benedito Antonio Lopes da Fonseca, Leandro Dorigan de Macedo, Karen Mirna Loro Morejón, Raphael Jurca Gonçalves da Motta, Tábata Larissa Dos Santos Pólvora, Atila Vinícius Vitor Nobre, Kelly R.V. Villafuerte, Alan Grupioni Lourenço, Maria da Conceição Pereira Saraiva, Letícia Richard Miranda Silva, João Henrique Parise Fortes, Ana Laura Polizel Ranieri, Vanessa De Oliveira Teles, Mário Taba, Gilberto A. Silva, Camila Tirapelli |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty medicine.medical_treatment HIV Infections Gastroenterology 03 medical and health sciences 0302 clinical medicine Pharmacotherapy Internal medicine Antiretroviral Therapy Highly Active medicine Humans Candida Periodontitis Colony-forming unit business.industry HIV Interleukin 030206 dentistry Periodontium Viral Load medicine.disease Chronic periodontitis 030104 developmental biology Cytokine Chronic Periodontitis Periodontics business Viral load |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1943-3670 |
| Popis: | Background After the introduction of antiretroviral therapy (ART), human immunodeficiency virus (HIV) infection has become a chronic controllable disease. For this reason, chronic conditions related to both HIV infection and senescence, such as chronic periodontitis (CP) need to be studied. This study investigated the impact of non-surgical periodontal therapy (NSPT) on clinical and immunological features of CP, and on oral colonization by Candida spp. in HIV-infected and non-HIV-infected individuals. Methods HIV-infected (test group) and non-HIV-infected (control group) adults patients with CP were selected. Gingival bleeding index (GI), probing depth (PD), clinical attachment level (CAL), number of teeth, CD4+ T lymphocytes and viral load (only for HIV-infected individuals), salivary cytokines (interleukin, [IL]-6, IL-8, and tumoral necrosis factor-alpha [TNF-α]), and oral Candida infection (colony forming units and species) were assessed at baseline, and 30 and 90 days after NSPT. Results Twenty-two HIV-infected patients and 20 non-HIV-infected patients were evaluated. Candida counts and salivary IL-6, IL-8, and TNF-a levels were higher in the test group than in the control group. Both groups showed a decrease in oral Candida counts, GI, PD, IL-6, and IL-8 as well as gain in CAL at 30 and 90 days after NSPT. In addition, patients in the test group showed an increase of CD4+ T lymphocytes and a decrease of viral load. Conclusion NSPT had a beneficial impact on clinical and immunological parameters of CP, reduction of oral Candida counts, and improvement of HIV-infection status. |
| Databáze: | OpenAIRE |
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