Magnetic Catechin–Dextran conjugate as targeted therapeutic for pancreatic tumour cells
| Autor: | Valerio Voliani, Francesca Iemma, Silke Hampel, Giuseppe Cirillo, Biswajit Karmakar, Orazio Vittorio, Paolo Faraci, Maria Kavallaris |
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| Přispěvatelé: | Orazio, Vittorio, Voliani, Valerio, Faraci, Paolo Mario, Biswajit, Karmakar, Francesca, Iemma, Silke, Hampel, Maria, Kavallari, Giuseppe, Cirillo |
| Rok vydání: | 2014 |
| Předmět: |
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Cell Survival Cell Culture Techniques Pharmaceutical Science Antineoplastic Agents Apoptosis Nanoconjugates Pharmacology Anticancer activity Catechin chemistry.chemical_compound Cell Line Tumor Humans Scattering Radiation Magnetite Nanoparticles Dextran Dextrans Pancreatic tumour equipment and supplies chemistry Magnetic nanoparticles Cancer cell Polymer therapeutics human activities Conjugate |
| Zdroj: | Journal of drug targeting 22 (2014): 408–415. doi:10.3109/1061186X.2013.878941 info:cnr-pdr/source/autori:Vittorio O.[ 1,2 ] ; Voliani V.[ 3,4,5 ] ; Faraci P.[ 3,4 ]; Karmakar B.[ 3,4,6 ]; Iemma F.[ 7 ]; Hampel S.[ 8 ] ; Kavallaris M.[ 1,2 ]; Cirillo G.[ 7,8 ]/titolo:Magnetic catechin-dextran conjugate as targeted therapeutic for pancreatic tumour cells/doi:10.3109%2F1061186X.2013.878941/rivista:Journal of drug targeting (Print)/anno:2014/pagina_da:408/pagina_a:415/intervallo_pagine:408–415/volume:22 |
| Popis: | Background: Catechin-dextran conjugates have recently attracted a lot of attention due to their anticancer activity against a range of cancer cells. Magnetic nanoparticles have the ability to concentrate therapeutically important drugs due to their magnetic-spatial control and provide opportunities for targeted drug delivery. Purpose: Enhancement of the anticancer efficiency of catechin-dextran conjugate by functionalisation with magnetic iron oxide nanoparticles. Methods: Modification of the coating shell of commercial magnetic nanoparticles (Endorem) composed of dextran with the catechin-dextran conjugate. Results: Catechin-dextran conjugated with Endorem (Endo-Cat) increased the intracellular concentration of the drug and it induced apoptosis in 98% of pancreatic tumour cells placed under magnetic field. Discussion: The conjugation of catechin-dextran with Endorem enhances the anticancer activity of this drug and provides a new strategy for targeted drug delivery on tumour cells driven by magnetic field. Conclusion: The ability to spatially control the delivery of the catechin-dextran by magnetic field makes it a promising agent for further application in cancer therapy. © 2014 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted. |
| Databáze: | OpenAIRE |
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