Serum eotaxin-1 is increased in extremely-low-birth-weight infants with bronchopulmonary dysplasia or death

Autor: Namasivayam Ambalavanan, Jegen Kandasamy, Alexander J. Szalai, Claire Roane
Rok vydání: 2015
Předmět:
Male
Eotaxin
Pediatrics
Time Factors
Systemic inflammation
Gastroenterology
0302 clinical medicine
Risk Factors
Infant Mortality
Birth Weight
Hospital Mortality
030212 general & internal medicine
Bronchopulmonary Dysplasia
biology
Age Factors
respiratory system
Up-Regulation
3. Good health
C-Reactive Protein
Infant
Extremely Low Birth Weight
Regression Analysis
Female
medicine.symptom
Chemokine CCL11
medicine.medical_specialty
Birth weight
Enzyme-Linked Immunosorbent Assay
Lung injury
Risk Assessment
behavioral disciplines and activities
Article
03 medical and health sciences
Neonatal Screening
030225 pediatrics
Internal medicine
mental disorders
medicine
Humans
business.industry
C-reactive protein
Infant
Newborn
Infant
Stepwise regression
medicine.disease
respiratory tract diseases
Low birth weight
Bronchopulmonary dysplasia
Pediatrics
Perinatology and Child Health
biology.protein
business
Biomarkers
Zdroj: Pediatric research
ISSN: 1530-0447
0031-3998
DOI: 10.1038/pr.2015.152
Popis: Early systemic inflammation in extremely-low-birth-weight (ELBW) infants is associated with an increased risk of bronchopulmonary dysplasia (BPD). Our objective was to identify circulating biomarkers and develop prediction models for BPD/death soon after birth. Blood samples from postnatal day 1 were analyzed for C-reactive protein (CRP) by enzyme-linked immunosorbent assay and for 39 cytokines/chemokines by a multiplex assay in 152 ELBW infants. The primary outcome was physiologic BPD or death by 36 wk. CRP, cytokines, and clinical variables available at ≤24 h were used for forward stepwise regression and Classification and Regression Tree (CART) analysis to identify predictors of BPD/death. Overall, 24% developed BPD and 35% died or developed BPD. Regression analysis identified birth weight and eotaxin (CCL11) as the two most significant variables. CART identified FiO2 at 24 h (11% BPD/death if FiO2 ≤28%, 49% if >28%) and eotaxin in infants with FiO2 > 28% (29% BPD/death if eotaxin was ≤84 pg/ml; 65% if >84) as variables most associated with outcome. Eotaxin measured on the day of birth is useful for identifying ELBW infants at risk of BPD/death. Further investigation is required to determine if eotaxin is involved in lung injury and pathogenesis of BPD.
Databáze: OpenAIRE
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