National practice patterns of proton versus photon therapy in the treatment of adult patients with primary brain tumors in the United States
| Autor: | Adams Kusi Appiah, Vaishnavi Ganesan, Jeffrey M. Ryckman, Chi Zhang, Vivek Verma |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty MEDLINE 030218 nuclear medicine & medical imaging National cohort 03 medical and health sciences 0302 clinical medicine Text mining Internal medicine Proton Therapy medicine Humans Radiology Nuclear Medicine and imaging Practice Patterns Physicians' Primary Brain Tumors Aged Patterns of care Photons Radiotherapy Adult patients Brain Neoplasms business.industry Practice patterns Hematology General Medicine Middle Aged United States Socioeconomic Factors Oncology 030220 oncology & carcinogenesis Female Photon therapy business |
| Zdroj: | Acta Oncologica. 58:66-73 |
| ISSN: | 1651-226X 0284-186X |
| DOI: | 10.1080/0284186x.2018.1512755 |
| Popis: | To examine patterns of care associated with the administration of proton versus photon therapy for adult patients with primary brain tumors in a large national cohort from the United States.The National Cancer Database (NCDB) was queried for newly diagnosed primary brain tumors (2004-2014) in adult patients aged 18 and older receiving proton or photon radiotherapy. Clinical features, patient demographics and treatment parameters were extracted. Differences between groups were assessed using multivariable logistic regression analysis.In total, 73,073 patients were analyzed (n = 72,635 [99.4%] photon therapy, n = 438 [0.6%] proton therapy). On multivariable analysis of photon versus proton therapy, several factors predicted for receipt of proton therapy, including younger age (p = .041), highest income quartile (p = .007), treatment at academic institutions (p.001), in regional facilities outside the Midwest/South (p.001), diagnosis in more recent years (p = .003), fewer comorbidities (p.001) and non-glioblastoma histology (p.001).There are several significant socioeconomic variables that influence receipt of proton therapy for primary brain tumors. Although not implying causation, the socioeconomic findings discovered herein should be taken into account when delivering cancer care to all patients. |
| Databáze: | OpenAIRE |
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