TGR5: an emerging bile acid G-protein-coupled receptor target for the potential treatment of metabolic disorders
| Autor: | Pranab Maiti, Atul Tiwari |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pharmacology
Bile acid medicine.drug_class Biology Models Biological G protein-coupled bile acid receptor Energy homeostasis Receptors G-Protein-Coupled Bile Acids and Salts Drug Delivery Systems Glucose Metabolic Diseases Nuclear receptor Biochemistry Drug Discovery medicine Animals Homeostasis Humans Glucose homeostasis Farnesoid X receptor Energy Metabolism Receptor G protein-coupled receptor |
| Zdroj: | Drug Discovery Today. 14:523-530 |
| ISSN: | 1359-6446 |
| DOI: | 10.1016/j.drudis.2009.02.005 |
| Popis: | Over the past decade, new roles for bile acids in paracrine and endocrine regulation of cholesterol homeostasis, lipid and carbohydrate metabolism and immunomodulatory functions have been discovered. Most of the early discoveries focused on the genomic actions of bile acids through the activation of families of nuclear receptors, such as the farnesoid X receptor and vitamin D receptors, until a new chapter in the bile acid receptor discovery unfolded in the form of TGR5; a novel G-protein-coupled receptor mediating several non-genomic functional responses induced by binding of bile acids. The key involvement of TGR5 in mediating energy homeostasis and glucose homeostasis made it an attractive target for the potential treatment of metabolic disorders. |
| Databáze: | OpenAIRE |
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