Magnolol protects against cerebral ischaemic injury of rat heatstroke
| Autor: | MT Lin, YC Hsu, CP Chang |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Mean arterial pressure Hot Temperature Physiology Heat Stroke Ischemia Lignans Brain Ischemia Rats Sprague-Dawley Lipid peroxidation chemistry.chemical_compound Physiology (medical) Internal medicine Animals Medicine Cerebral perfusion pressure Intracranial pressure Pharmacology Hydroxyl Radical business.industry Biphenyl Compounds Heatstroke medicine.disease Corpus Striatum Magnolol Rats Endocrinology chemistry Cerebral blood flow Anesthesia Lipid Peroxidation business |
| Zdroj: | Clinical and Experimental Pharmacology and Physiology. 30:387-392 |
| ISSN: | 1440-1681 0305-1870 |
| Popis: | Summary 1. Free radicals mediate cerebral ischaemic injury associated with heatstroke. Magnolol, an active component of Magnolia officinalis, is 1000-fold more potent than α-tocopherol in inhibiting lipid peroxidation in rat mitochondria. The aim of the present study was to ascertain whether magnolol attenuated cerebral ischaemic injury and free radical formation associated with heatstroke. 2. Urethane-anaesthetized rats were exposed to heat stress (ambient temperature 42°C) to induce heatstroke. Controlled rats were exposed to 24°C. Mean arterial pressure, cerebral perfusion pressure and cerebral blood flow after the onset of heatstroke were all significantly lower than in control rats. However, colonic temperature, intracranial pressure, heart rate, cerebral free radicals, lipid peroxidation and the neuronal damage score were greater after the onset of heatstroke. 3. Magnolol (20 or 40 mg/kg, i.v.) significantly attenuated the heatstroke-induced hyperthermia, arterial hypotension, intracranial hypertension, cerebral ischaemia and neuronal damage and increased free radical formation and lipid peroxidation in the brain. The extracellular concentrations of ischaemic (e.g. glutamate and lactate/pyruvate ratio) and damage (e.g. glycerol) markers in the corpus striatum were increased after the onset of heatstroke. Magnolol significantly attenuated the increase in striatal ischaemia and damage markers associated with heatstroke. 4. Thus, it appears that magnolol has impressive effects against heatstroke reactions. |
| Databáze: | OpenAIRE |
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