Polymorphisms of cancer stem cell marker gene CD133 are associated with susceptibility and prognosis of gastric cancer
| Autor: | Jing Jiang, Xueyuan Cao, Donghui Cao, Yanhua Wu, Bao-Sen Zhou, Zhifang Jia |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Oncology Cancer Research medicine.medical_specialty Genotype medicine.medical_treatment Single-nucleotide polymorphism Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms Cancer stem cell Internal medicine Biomarkers Tumor Odds Ratio medicine Genetic predisposition Humans Genetic Predisposition to Disease AC133 Antigen Alleles Aged Neoplasm Staging Chemotherapy biology business.industry Hazard ratio CD44 General Medicine Odds ratio Middle Aged Prognosis Hyaluronan Receptors 030104 developmental biology 030220 oncology & carcinogenesis Neoplastic Stem Cells biology.protein Female business |
| Zdroj: | Future Oncology. 13:979-989 |
| ISSN: | 1744-8301 1479-6694 |
| DOI: | 10.2217/fon-2017-0019 |
| Popis: | Aim: This study was aimed to investigate the associations between single nucleotide polymorphisms of cancer stem cell marker genes, CD44 and CD133, and susceptibility and prognosis of gastric cancer. Patients & methods: Five single nucleotide polymorphisms in CD44 and CD133 genes were genotyped in 898 gastric cancer cases and 992 controls. Results: The A/C or C/C genotypes of CD133 rs2240688 were associated with decreased risk of gastric cancer comparing with the A/A genotype (odds ratio: 0.81; 95% CI: 0.67–0.97; p = 0.023). The T allele of CD133 rs3130 predicted a worse survival for gastric cancer patients receiving tumorectomy (hazard ratio: 1.28; 95% CI: 1.04–1.58; p = 0.020), independent from tumor node metastasis stage, vessel invasion and postoperational chemotherapy. Conclusion: CD133 polymorphisms are promising biomarkers for genetic susceptibility and prognosis prediction of gastric cancer. |
| Databáze: | OpenAIRE |
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