Dynamic potential and surface morphology study of sertraline membrane sensors
| Autor: | H.B. Hassib, M. M. Khater, Saada Mohammed, Yousry M. Issa |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Detection limit
lcsh:R5-920 Multidisciplinary Sensors Potentiometric titration Heteropolyacids Nanotechnology Silicotungstic acid Sertraline Hydrochloride chemistry.chemical_compound Membrane chemistry Sertraline hydrochloride SEM Sodium tetraphenylborate Phosphomolybdic acid Original Article Titration AFM General lcsh:Medicine (General) lcsh:Science (General) lcsh:Q1-390 Nuclear chemistry |
| Zdroj: | Journal of Advanced Research, Vol 6, Iss 3, Pp 459-469 (2015) Journal of Advanced Research |
| ISSN: | 2090-1232 |
| DOI: | 10.1016/j.jare.2014.11.005 |
| Popis: | New rapid, sensitive and simple electrometric method was developed to determine sertraline hydrochloride (Ser-Cl) in its pure raw material and pharmaceutical formulations. Membrane sensors based on heteropolyacids as ion associating material were prepared. Silicomolybdic acid (SMA), silicotungstic acid (STA) and phosphomolybdic acid (PMA) were used. The slope and limit of detection are 50.00, 60.00 and 53.24mV/decade and 2.51, 5.62 and 4.85μmolL−1 for Ser-ST, Ser-PM and Ser-SM membrane sensors, respectively. Linear range is 0.01–10.00 for the three sensors. These new sensors were used for the potentiometric titration of Ser-Cl using sodium tetraphenylborate as titrant. The surface morphologies of the prepared membranes with and without the modifier (ion-associate) were studied using scanning and atomic force microscopes. |
| Databáze: | OpenAIRE |
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