Effect of contrasted levels of habitual physical activity on metabolic flexibility
| Autor: | Dale A. Schoeller, Guillemette Gauquelin-Koch, Edwina Antoun, Iman Momken, Stéphane Blanc, Chantal Simon, Audrey Bergouignan |
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| Přispěvatelé: | Département Ecologie, Physiologie et Ethologie (DEPE-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Faculté de médecine (EA1801), Department of Nutritional Sciences, University of Wisconsin-Madison, Centre National d'Études Spatiales [Toulouse] (CNES), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), National Program in Human Nutrition (Institut National de la Sante et de la Recherche Medicale and Institute National de la Recherche Agronomique), Fondation Coeur et Arteres, Fondation Louis D., Hopitaux Universitaire de Strabsourg (API- HUS) (France) [3493], Centre national d'etudes spatiales (CNES), European Space Agency, CNES, Alsace Region fellowship, University Louis Pasteur of Strasbourg (France), Fondation pour la Recherche Medicale |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty insulin Physiology medicine.medical_treatment 030209 endocrinology & metabolism Context (language use) Overweight Carbohydrate metabolism Motor Activity 03 medical and health sciences Young Adult 0302 clinical medicine Metabolic Diseases Physiology (medical) Internal medicine [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] Medicine Humans Exercise physiology Pliability Exercise 030304 developmental biology detraining 0303 health sciences Meal training business.industry Insulin fat oxidation Physical activity level humanities Respiratory quotient Kinetics Endocrinology [SDE]Environmental Sciences physical inactivity Female medicine.symptom business Energy Metabolism |
| Zdroj: | Journal of Applied Physiology Journal of Applied Physiology, American Physiological Society, 2013, 114, pp.371-379. ⟨10.1152/japplphysiol.00458.2012⟩ Journal of Applied Physiology, American Physiological Society, 2013, 114 (3), pp.371-379. ⟨10.1152/japplphysiol.00458.2012⟩ |
| ISSN: | 8750-7587 1522-1601 |
| DOI: | 10.1152/japplphysiol.00458.2012⟩ |
| Popis: | The factors regulating the body's ability to switch from fat to carbohydrate oxidation in response to fuel availability changes, or metabolic flexibility (MF), are currently intensively investigated in the context of metabolic diseases. Although numerous metabolic diseases are associated with sedentary behaviors and metabolic inflexibility, the effect of habitual physical activity level (PAL) on MF regulation is surprisingly poorly known. We investigated how PAL affects MF in cross-sectional and interventional studies. MF was assessed in 44 subjects: normal-weight and overweight sedentary men submitted to 2 mo of exercise at current recommendations, normal-weight active men submitted to 1 mo of reduced PAL and normal-weight women submitted to 1 mo of bed rest, with or without exercise. MF was evaluated, before and after interventions, following two standard meals as the relationship between individual mathematical variances in insulin and nonprotein respiratory quotient (NPRQ) daily kinetics. Daily NPRQ and insulin variances differed according to habitual PAL ( P = 0.002 and P = 0.009, respectively); active subjects had higher variances in NPRQ for lower variances in insulin than sedentary subjects, indicating a better MF. Detraining increased insulin variance ( P = 0.009) and decreased NPRQ variance ( P = 0.003), while training tended to have opposite effects. Insulin and NPRQ variances were negatively related along the PAL continuum ( R2 = 0.70, P < 0.001). Variance in NPRQ was also positively related to PAL ( R2 = 0.52, P < 0.001). By assessing MF with mathematical surrogates in conditions of daily pattern in meal's intake, we showed that habitual PAL is associated with MF status, and that MF is modulated by changes in PAL. |
| Databáze: | OpenAIRE |
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