Increased vasoconstrictor reactivity and decreased endothelial function in high grade varicocele; functional and morphological study
| Autor: | Oguzhan Yildiz, Onder Onguru, Husamettin Gul, Ahmet Aydin, Askin Isimer, A. Cetin Harmankaya, Mete Kilciler, Yasar Ozgok |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Endothelium Urology Varicocele In Vitro Techniques Severity of Illness Index Norepinephrine (medication) chemistry.chemical_compound Internal medicine medicine Humans Vasoconstrictor Agents Endothelial dysfunction Cyclic guanosine monophosphate Phenylephrine biology medicine.disease Nitric oxide synthase medicine.anatomical_structure Endocrinology chemistry Vasoconstriction biology.protein Endothelium Vascular medicine.symptom Muscle Contraction medicine.drug |
| Zdroj: | Urological Research. 31:323-328 |
| ISSN: | 1434-0879 0300-5623 |
| DOI: | 10.1007/s00240-003-0343-0 |
| Popis: | The pathophysiology of human varicocele is not fully understood. We investigated vasoconstrictor reactivity, endothelial function and morphological changes in different grades of varicocele to clarify the pathophysiology. Contractile responses to phenylephrine, norepinephrine, serotonin and histamine were determined in isolated human varicose spermatic veins using the organ bath technique. Endothelial function was tested with acetylcholine-induced relaxation after phenylephrine-induced precontraction in the absence and presence of nitric oxide synthase inhibitor, L-NAME, and cyclooxygenase inhibitor, indomethacin. The cyclic guanosine monophosphate (cGMP) level was measured in the spermatic vein and peripheral plasma. Morphological changes were evaluated with light microscopy. Phenylephrine, norepinephrine, serotonin and histamine induced concentration-dependent contractions. The maximum contractions for all of these agents except norepinephrine were significantly higher in grade III than grade I and II (P |
| Databáze: | OpenAIRE |
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