Cytotoxic effects of C-glycosides in HOS and HeLa cell lines
| Autor: | Rubén P. Machı´n, Carlos Mayato, Jesús T. Vázquez, José M. Padrón, Carlos A. Sanhueza, Rosa L. Dorta |
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| Rok vydání: | 2007 |
| Předmět: |
Clinical Biochemistry
Pharmaceutical Science Antineoplastic Agents Bone Neoplasms Biochemistry HeLa Inhibitory Concentration 50 Structure-Activity Relationship Cell Line Tumor Drug Discovery Humans Cytotoxic T cell Structure–activity relationship Glycosides Cytotoxicity Molecular Biology Cell Proliferation chemistry.chemical_classification Osteosarcoma biology Cell growth Chemistry Organic Chemistry Glycoside Stereoisomerism biology.organism_classification Molecular biology In vitro Models Chemical Cell culture Molecular Medicine Drug Screening Assays Antitumor HeLa Cells |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 17:3676-3681 |
| ISSN: | 0960-894X |
| Popis: | Fifty-two C-glycosides were synthesized and their in-vitro antiproliferative activity screened against human cervical carcinoma (HeLa) and osteosarcoma (HOS) cell lines. Nine of them had growth inhibitions (GI(50) values) below 10 microM, the C-glucopyranoside 38 being the most active against HeLa (5.4 microM) and the dichlorocyclopropyl derivative 42 against HOS (1.6 microM). Some preliminary structure-activity relationships were established. |
| Databáze: | OpenAIRE |
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