Maternal-fetal Complications in Pregnancy: A Retrospective Comparison Between Type 1 and Type 2 Diabetes Mellitus
| Autor: | Emanuela Giacchetto, Valentina Guarnotta, Mariagrazia Irene Mineo, Maria P. Imbergamo, Carla Giordano |
|---|---|
| Přispěvatelé: | Guarnotta V, Mineo MI, Giacchetto E, Imbergamo MP, Giordano C. |
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Multivariate analysis endocrine system diseases medicine.medical_treatment Reproductive medicine 030209 endocrinology & metabolism Abortion Macrosomia lcsh:Gynecology and obstetrics Body Mass Index Fetal Macrosomia 03 medical and health sciences Young Adult 0302 clinical medicine Pregnancy Risk Factors Insulin requirement medicine Prevalence Humans Insulin lcsh:RG1-991 Retrospective Studies Glycated Hemoglobin 030219 obstetrics & reproductive medicine Obstetrics business.industry Obstetrics and Gynecology Type 2 Diabetes Mellitus nutritional and metabolic diseases medicine.disease Gestational Weight Gain Abortion Spontaneous Diabetes Mellitus Type 1 Diabetes Mellitus Type 2 Large for gestational age Cohort Female Pregnancy Trimesters medicine.symptom Insulin Resistance business Weight gain Research Article |
| Zdroj: | BMC Pregnancy and Childbirth, Vol 21, Iss 1, Pp 1-10 (2021) BMC Pregnancy and Childbirth |
| Popis: | Background The aim of the study was a retrospective comparison of the differences in maternal-foetal outcomes between women with type 1 and type 2 diabetes mellitus (T1DM and T2DM). Methods A cohort of 135 patients with pregestational diabetes, 73 with T1DM (mean age 29 ± 5 years) and 62 with T2DM (mean age 33 ± 6 years), in intensive insulin treatment throughout pregnancy were evaluated. Clinical and metabolic parameters and the prevalence of maternal and foetal complications were assessed. Results Women with T1DM showed lower pregestational BMI (p p p p p p = 0.040), HbA1c in the first (p = 0.004), second (p = 0.020) and third (p = 0.010) trimesters compared to T2DM. Women with T1DM had a higher risk of macrosomia (p = 0.005) than T2DM, while women with T2DM showed higher prevalence of abortion (p = 0.037) than T1DM. At multivariate analysis, pregestational BMI and ∆_total_IR of the first trimester were independently associated with abortion in T2DM, while weight gain during pregnancy was independently associated with macrosomia in T1DM. Conclusion Women with T1DM have a higher risk of macrosomia than T2DM due to weight gain throughout pregnancy. By contrast, women with T2DM have a higher risk of spontaneous abortion than T1DM, due to pregestational BMI and ∆_total_IR in the first trimester. |
| Databáze: | OpenAIRE |
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