Carbon-nanotube amperometric sensor for selective determination of 4-chloroaniline in commercial chlorhexidine solutions
| Autor: | Vagner Bezerra dos Santos, Denis Tadeu Rajh Vidal, Rodrigo H. O. Montes, Ana P. Lima, Rodrigo A.A. Munoz, Eduardo M. Richter, Claudimir Lucio do Lago |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
Capillary action NANOTECNOLOGIA 02 engineering and technology Carbon nanotube Mass spectrometry 01 natural sciences law.invention chemistry.chemical_compound law Materials Chemistry medicine Electrical and Electronic Engineering Instrumentation Detection limit Chromatography 010401 analytical chemistry Chlorhexidine Metals and Alloys 4-Chloroaniline 021001 nanoscience & nanotechnology Condensed Matter Physics Amperometry 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry Electrode 0210 nano-technology medicine.drug |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 0925-4005 |
| DOI: | 10.1016/j.snb.2016.02.139 |
| Popis: | This work reports a carbon-nanotube amperometric sensor for the selective determination of 4-chloroaniline (4-CLA), the major degradation product found in commercial chlorhexidine solutions. The harmful 4-CLA is detected on a multi-walled carbon nanotube (MWCNT)-modified electrode, free from the interference of chlorhexidine and other substances present in such samples, with a detection limit of 50 nmol L −1 . MWCNTs of two different dimensions were evaluated for 4-CLA detection and a 3-fold increase in sensitivity using both modified electrodes was obtained in comparison with the bare electrode. The association of batch-injection analysis with the amperometric detection provided high precision (1.2%) and sample throughput (130 h −1 ). Analyses of samples by capillary electrophoresis-tandem mass spectrometry (CE-MS/MS) attested the accuracy of the proposed method. Mouth rinse and skin disinfectant samples presented 4-CLA concentrations in the range between 4 and 235 μmol L −1 . |
| Databáze: | OpenAIRE |
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