Crystallographic and spectroscopic characterization of 2-[(7-acetyl-4-cyano-6-hydroxy-1,6-dimethyl-8-phenyl-5,6,7,8-tetrahydroisoquinolin-3-yl)sulfanyl]-N-phenylacetamide
| Autor: | Shaaban K. Mohamed, Etify A. Bakhite, Islam S. Maraei, Güneş Demirtaş, Joel T. Mague, Elham A. Al-Taifi, Youssef Ramli |
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| Rok vydání: | 2021 |
| Předmět: |
crystal structure
phenylacetamide phenylacetamide Crystal structure 010402 general chemistry 010403 inorganic & nuclear chemistry Ring (chemistry) 01 natural sciences Medicinal chemistry Research Communications Crystal chemistry.chemical_compound c—h...π(ring) interaction General Materials Science Quantitative Biology::Biomolecules hydrogen bond Crystallography biology Hydrogen bond Chemistry Tetrahydroisoquinoline General Chemistry Condensed Matter Physics biology.organism_classification 0104 chemical sciences tetrahydroisoquinoline QD901-999 Tetra C—H⋯π(ring) interaction tetrahydroisoquinoline Acetamide |
| Zdroj: | Acta Crystallographica Section E: Crystallographic Communications Acta Crystallographica Section E: Crystallographic Communications, Vol 77, Iss 2, Pp 121-125 (2021) |
| ISSN: | 2056-9890 |
| Popis: | The heterocyclic portion of the tetrahydroisoquinoline unit is planar and an intramolecular N—H⋯N hydrogen bond and a C—H⋯π(ring) interaction help to determine the overall conformation. In the crystal, O—H⋯O hydrogen bonds form inversion dimers, which are connected by C—H⋯O hydrogen bonds, forming layers parallel to (10). In the title molecule, C28H27N3O3S, the heterocyclic portion of the tetrahydroisoquinoline unit is planar and an intramolecular N—H⋯N hydrogen bond and a C—H⋯π(ring) interaction help to determine the overall conformation. In the crystal, a layer structure with the layers parallel to (10) is generated by O—H⋯O and C—H⋯O hydrogen bonds. |
| Databáze: | OpenAIRE |
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