Ascorbic acid combats arsenic-induced oxidative stress in mice liver
| Autor: | Philippe Belon, Nandini Bhattacharjee, Naoual Boujedaini, Surajit Pathak, Anisur Rahman Khuda-Bukhsh, Pathikrit Banerjee, Soumya Sundar Bhattacharyya |
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| Rok vydání: | 2008 |
| Předmět: |
Antioxidant
Health Toxicology and Mutagenesis medicine.medical_treatment Glutathione reductase Ascorbic Acid Pharmacology medicine.disease_cause Antioxidants Arsenic Lipid peroxidation chemistry.chemical_compound Mice Arsenic Poisoning medicine Animals Arsenic trioxide Micronucleus Tests Arsenic toxicity Chemistry Public Health Environmental and Occupational Health General Medicine Glutathione Ascorbic acid Pollution Enzyme Activation Microscopy Electron Oxidative Stress Biochemistry Liver Oxidative stress Biomarkers |
| Zdroj: | Ecotoxicology and environmental safety. 72(2) |
| ISSN: | 1090-2414 |
| Popis: | Repeated injections of arsenic trioxide induced oxidative stress and hepatotoxicity in mice as revealed from elevated levels of glutamate oxaloacetate transaminases, glutamate pyruvate transaminases, acid and alkaline phosphatases, lipid peroxidation along with reduction of superoxide dismutase, catalase, reduced glutathione content, glutathione reductase and succinate dehydrogenase activities. The present investigation was undertaken to test whether simultaneous feeding of Vitamin-C can combat hepatotoxicity in arsenic intoxicated mice. Hepatoprotective potential of Vitamin-C was indicated by its ability to restore GSH, SOD, CAT, AcP, AlkP and GRD levels towards near normal. Electron microscopic studies further supported the biochemical findings confirming the hepatoprotective potential of ascorbic acid. Besides, cytogenetical endpoints (chromosome aberrations, micronuclei, mitotic index and sperm head anomaly) were also analyzed. Administration of Vitamin-C alone did not show any sign of toxicity of its own. Based on the present findings, ascorbic acid appears to have protective effects against arsenic toxicity and oxidative stress. |
| Databáze: | OpenAIRE |
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