Chronic Toxicity of Methyl Linoleate Hydroperoxide for the Rabbit
| Autor: | M. G. Kokatnur, J. G. Bergan, H.H. Draper |
|---|---|
| Rok vydání: | 1966 |
| Předmět: |
medicine.medical_specialty
Necrosis medicine.medical_treatment chemistry.chemical_element Creatine Hemolysis Muscular Dystrophies General Biochemistry Genetics and Molecular Biology Selenium chemistry.chemical_compound Oral administration Internal medicine medicine Animals Vitamin E Chronic toxicity medicine.disease Peroxides Endocrinology Linoleic Acids chemistry Toxicity Rabbits medicine.symptom |
| Zdroj: | Experimental Biology and Medicine. 123:254-258 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-123-31459 |
| Popis: | SummarySmall quantities of purified methyl linoleate hydroperoxide (MLHP) were administered by daily intravenous injection (50 mg/day) or by continuous intravenous infusion (206 μg/min) to rabbits depleted of their vitamin E stores. After 10-14 days the injected animals exhibited fatty degeneration and necrosis of the liver, cre-atinuria and an increased incidence of muscular incoorduration. The creatinuria was prevented by large oral doses of vitamin E (100 mg/day) but sodium selenite had no effect on the creatinuria or the incidence of liver lesions. Infusion of MLHP for 26-30 hr led to an increased fragility of the red blood cells and a marked creatinuria. These results indicate that chronic administration of small quantities of MLHP leads to a more rapid destruction of vitamin E in the tissues and an accelerated appearance of deficiency symptoms. |
| Databáze: | OpenAIRE |
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