New insights into early-life stress and behavioral outcomes
| Autor: | Autumn S Ivy, Jessica L. Bolton, Tallie Z. Baram, Jenny Molet |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cognitive Neuroscience media_common.quotation_subject Psychological intervention Early life stress Vulnerability Anhedonia Parental presence Cognition Article Developmental psychology Pleasure 03 medical and health sciences Behavioral Neuroscience Psychiatry and Mental health 030104 developmental biology 0302 clinical medicine Stress (linguistics) medicine medicine.symptom Psychology 030217 neurology & neurosurgery media_common |
| Zdroj: | Current Opinion in Behavioral Sciences. 14:133-139 |
| ISSN: | 2352-1546 |
| DOI: | 10.1016/j.cobeha.2016.12.012 |
| Popis: | Adverse early-life experiences, including various forms of early-life stress, have consistently been linked with vulnerability to cognitive and emotional disorders later in life. Understanding the mechanisms underlying the enduring consequences of early-life stress is an active area of research, because this knowledge is critical for developing potential interventions. Animal models of early-life stress typically rely on manipulating maternal/parental presence and care, because these are the major source of early-life experiences in humans. Diverse models have been created, and have resulted in a wealth of behavioral outcomes. Here we focus on recent findings highlighting early-life stress-induced behavioral disturbances, ranging from hippocampus-dependent memory deficits to problems with experiencing pleasure (anhedonia). The use of naturalistic animal models of chronic early-life stress provides insight into the spectrum of cognitive and emotional outcomes and enables probing the underlying mechanisms using molecular-, cellular-, and network-level approaches. |
| Databáze: | OpenAIRE |
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