Molecular and immune targets for Merkel cell carcinoma therapy and prevention
| Autor: | Leah Cohen, Kenneth Y. Tsai |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research Skin Neoplasms Carcinogenesis medicine.medical_treatment Antineoplastic Agents Biology medicine.disease_cause Malignancy Targeted therapy 03 medical and health sciences 0302 clinical medicine Immune system medicine Animals Humans Molecular Biology Tumor biology Merkel cell carcinoma food and beverages Cancer Immunotherapy medicine.disease Carcinoma Merkel Cell 030104 developmental biology 030220 oncology & carcinogenesis Mutation Cancer research |
| Zdroj: | Molecular Carcinogenesis. 58:1602-1611 |
| ISSN: | 1098-2744 0899-1987 |
| Popis: | Merkel cell carcinoma (MCC) is a rare neuroendocrine carcinoma of the skin, for which the exact mechanisms of carcinogenesis remain unknown. Therapeutic options for this highly aggressive malignancy have historically been limited in both their initial response and response durability. Recent improvements in our understanding of MCC tumor biology have expanded therapeutic options for these patients, namely through the use of immunotherapies such as immune checkpoint inhibitors. Further elucidation of the tumor mutational landscape has identified molecular targets for therapies, which have demonstrated success in other cancer types. In this review, we discuss both current and investigational immune and molecular targets of therapy for MCC. |
| Databáze: | OpenAIRE |
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