A New Atisane-Type Diterpene from the Bark of the Mangrove Plant Excoecaria Agallocha
| Autor: | Jun De Chen, Peng Lin, Dan Qin Feng, Yi-Ming Lin, Cai Huan Ke, Zhan Chang Wang, Chong Ling Yan |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Models
Molecular Chemical structure Pharmaceutical Science Anti-microfouling Excoecaria agallocha Mass Spectrometry Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound Pseudomonas pseudoalcaligenes lcsh:Organic chemistry Drug Discovery Botany Plant Bark Animals Humans Physical and Theoretical Chemistry Nuclear Magnetic Resonance Biomolecular biology Communication Biofilm Organic Chemistry Euphorbiaceae biology.organism_classification chemistry Chemistry (miscellaneous) Biofilms visual_art visual_art.visual_art_medium Molecular Medicine Bark Mangrove Diterpene Diterpenes |
| Zdroj: | Molecules, Vol 14, Iss 1, Pp 414-422 (2009) Molecules |
| ISSN: | 1420-3049 |
| Popis: | A new atisane-type diterpene, ent-16alpha-hydroxy-atisane-3,4-lactone (4) and three known diterpenes, ent-16alpha-hydroxy-atisane-3-one (1), ent-atisane-3beta,16alpha-diol (2), ent-3,4-seco-16alpha-hydroxyatis- 4(19)-en -3-oic acid (3) were isolated from the bark of the mangrove plant Excoecaria agallocha. Their structures and relative stereochemistry were elucidated by means of extensive NMR and MS analysis. Compound 3 exhibited significant anti-microfouling activity against the adherence of Pseudomonas pseudoalcaligenes, with an EC(50) value of 0.54+/-0.01 ppm. |
| Databáze: | OpenAIRE |
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