Cell transplantation for the treatment of spinal cord injury - bone marrow stromal cells and choroid plexus epithelial cells
| Autor: | Norihiko Nakano, Chizuka Ide, Kenji Kanekiyo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
bone marrow stromal cell Pathology medicine.medical_specialty Stromal cell locomotor improvement lcsh:RC346-429 03 medical and health sciences 0302 clinical medicine Developmental Neuroscience Neurotrophic factors medicine Spinal cord injury lcsh:Neurology. Diseases of the nervous system Invited Review business.industry Regeneration (biology) axonal regeneration choroid plexus epithelial cell spinal cord injury intrinsic regeneration ability medicine.disease Spinal cord Transplantation 030104 developmental biology medicine.anatomical_structure Choroid plexus Bone marrow business 030217 neurology & neurosurgery |
| Zdroj: | Neural Regeneration Research, Vol 11, Iss 9, Pp 1385-1388 (2016) Neural Regeneration Research |
| ISSN: | 1673-5374 |
| Popis: | Transplantation of bone marrow stromal cells (BMSCs) enhanced the outgrowth of regenerating axons and promoted locomotor improvements of rats with spinal cord injury (SCI). BMSCs did not survive long-term, disappearing from the spinal cord within 2-3 weeks after transplantation. Astrocyte-devoid areas, in which no astrocytes or oligodendrocytes were found, formed at the epicenter of the lesion. It was remarkable that numerous regenerating axons extended through such astrocyte-devoid areas. Regenerating axons were associated with Schwann cells embedded in extracellular matrices. Transplantation of choroid plexus epithelial cells (CPECs) also enhanced axonal regeneration and locomotor improvements in rats with SCI. Although CPECs disappeared from the spinal cord shortly after transplantation, an extensive outgrowth of regenerating axons occurred through astrocyte-devoid areas, as in the case of BMSC transplantation. These findings suggest that BMSCs and CPECs secret neurotrophic factors that promote tissue repair of the spinal cord, including axonal regeneration and reduced cavity formation. This means that transplantation of BMSCs and CPECs promotes "intrinsic" ability of the spinal cord to regenerate. The treatment to stimulate the intrinsic regeneration ability of the spinal cord is the safest method of clinical application for SCI. It should be emphasized that the generally anticipated long-term survival, proliferation and differentiation of transplanted cells are not necessarily desirable from the clinical point of view of safety. |
| Databáze: | OpenAIRE |
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