Collateral flow in canine skeletal muscle

Autor: Hj. Hirche, P. Gaehtgens, Steinhagen C, J. Manthey, Vinzenz Hombach
Rok vydání: 1974
Předmět:
Zdroj: Pfl�gers Archiv European Journal of Physiology. 352:303-313
ISSN: 1432-2013
0031-6768
DOI: 10.1007/bf00585684
Popis: In the isolated canine semitendinosus muscle supplied by two separate arteries and veins entering and leaving the muscle at a distance of about 12 cm from each other blood flow, O2-content, andpO2 in all four vessels were measured. Using the dye dilution technique the distribution of arterial inflow on both veins was determined. It was found that the muscle portion supplied by one artery is not necessarily identical with the muscle portion drained by the corresponding vein. In 9 semitendinosi no dye could be found in the contralateral vein after indicator injection into one artery. Therefore, collateral flow (CF) in this type of muscle could be determinted after acute clamping of one artery by measuring venous outflow through the corresponding vein. CF was 4.9 ml · min−1 · 100 g−1 and could be increased by vasodilatation to 14.2 ml · min−1 · 100 g−1. Since after acute occlusion of one artery the VO2 did not decrease significantly CF can supply the tissue of the resting skeletal muscle sufficiently with O2. By measuring back flow (BF) in skeletal muscle CF is overestimated in a non-dilated vasculature and is underestimated in a dilated muscle vasculature. After embolization of the vasculature with microspheres (maximal diameter=40 μ) BF was less than 50% of CF measured during vasodilation. Therefore, in skeletal muscle more than 50% of CF passes through collateral vessels less than 40 μ in diameter.
Databáze: OpenAIRE
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