Additional file 1 of ABBV-176, a PRLR antibody drug conjugate with a potent DNA-damaging PBD cytotoxin and enhanced activity with PARP inhibition

Autor:	Anderson, Mark G., Zhang, Qian, Rodriguez, Luis E., Hecquet, Claudie M., Donawho, Cherrie K., Ansell, Peter J., Reilly, Edward B.
Rok vydání:	2021
Předmět:	body regions skin and connective tissue diseases
DOI:	10.6084/m9.figshare.14759832.v1
Popis:	Additional file 1: Fig. S1. Western blot analysis for PRLR in normal/nontransformed human cells. Panel A: HUVEC (umbilical vein endothelium), PrEC (prostate), HUF (primary uterine fibroblasts), NHBE (bronchial epithelium), HMEC (mammary epithelium), HRE (primary renal mixed epithelium), HRMC (renal mesangial cells), BT474 (breast cancer) as a positive control. Panel B: MCF10A (normal breast line), HMVEC (microvascular endothelium), and THLE-3 (immortalized liver). Examples of In vitro cell killing assay. Panel C: HMEC cells. Panel D: HRMC cells.
Databáze:	OpenAIRE
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