Linking genotype, cell behavior, and phenotype: multidisciplinary perspectives with a basis in zebrafish patterns
| Autor: | Alexandria Volkening |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Embryo
Nonmammalian animal structures Genotype Cell 03 medical and health sciences 0302 clinical medicine Morphogenesis Genetics medicine Animals Zebrafish Body Patterning 030304 developmental biology 0303 health sciences biology fungi Pigment cells biology.organism_classification Biological Evolution Phenotype medicine.anatomical_structure Evolutionary biology embryonic structures Fish 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Current Opinion in Genetics & Development. 63:78-85 |
| ISSN: | 0959-437X |
| Popis: | Zebrafish are characterized by dark and light stripes, but mutants display a rich variety of altered patterns. These patterns arise from the interactions of brightly colored pigment cells, making zebrafish a self-organization problem. The diversity of patterns present in zebrafish and other emerging fish models provides an excellent system for elucidating how genes, cell behavior, and visible animal characteristics are related. With the goal of highlighting how experimental and mathematical approaches can be used to link these scales, I overview current descriptions of zebrafish patterning, describe advances in the understanding of the mechanisms underlying cell communication, and discuss new work that moves beyond zebrafish to explore patterning in evolutionary relatives. |
| Databáze: | OpenAIRE |
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