Quinolones as gonadotropin releasing hormone (GnRH) antagonists: simultaneous optimization of the C(3)-aryl and C(6)-substituents

Autor:	Roy G. Smith, Song X. Huang, Matthew J. Wyvratt, Jane Lo, Thomas F. Walsh, Yi Tien Yang, Kang Cheng, Ning Ren, Irene Chen, Mark T. Goulet, Jonathan R. Young, Joel B. Yudkovitz, Robert J. DeVita
Rok vydání:	2000
Předmět:	Stereochemistry medicine.drug_class Aryl Organic Chemistry Clinical Biochemistry Antagonist Substituent Pharmaceutical Science Carboxamide Gonadotropin-releasing hormone Peptide hormone Quinolones Biochemistry Chemical synthesis Gonadotropin-Releasing Hormone chemistry.chemical_compound Structure-Activity Relationship chemistry Drug Discovery Lactam medicine Molecular Medicine Molecular Biology
Zdroj:	Bioorganicmedicinal chemistry letters. 10(15)
ISSN:	0960-894X
Popis:	A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (23h) was found to be optimal.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::273702354e5e688fb6fda23fbb065457 https://pubmed.ncbi.nlm.nih.gov/10937733 Zobrazit plný text záznamu Full Text from ScienceDirect