Pressure-compacted and spider silk-reinforced fibrin demonstrates sufficient biomechanical stability as cardiac patch in vitro

Autor:	Florian Helms, Alexander Horke, Axel Haverich, Melanie Klingenberg, Dmitry Bobylev, Ulrike Böer, Skadi Lau, Thomas Hassel, Markus Mlinaric, Elena Petená, Mathias Wilhelmi
Rok vydání:	2021
Předmět:	Fibrin Materials science biology Sutures Biomedical Engineering Silk In vitro Biomaterials Fibrin scaffold Tensile Strength Ultimate tensile strength biology.protein Spider silk Biomedical engineering
Zdroj:	Journal of biomaterials applications. 36(6)
ISSN:	1530-8022
Popis:	Objective: The generation of bio-/hemocompatible cardiovascular patches with sufficient stability and regenerative potential remains an unmet goal. Thus, the aim of this study was the generation and in vitro biomechanical evaluation of a novel cardiovascular patch composed of pressure-compacted fibrin with embedded spider silk cocoons. Methods: Fibrin-based patches were cast in a customized circular mold. One cocoon of Nephila odulis spider silk was embedded per patch during the casting process. After polymerization, the fibrin clot was compacted by 2 kg weight for 30 min resulting in thickness reduction from up to 2 cm to
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::273655a03dfe6eb76cabd8705136b5fb https://pubmed.ncbi.nlm.nih.gov/34617818 Zobrazit plný text záznamu