The 'metabolic burst' in polymorphonuclear leukocytes from patients with quiescent psoriasis
| Autor: | L.A.B. Joosten, J.P.M. Geerdink, P.W. Troost, Joost Schalkwijk, P.D. Mier |
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| Rok vydání: | 1985 |
| Předmět: |
Adult
Metabolic burst Neutrophils Dermatology law.invention chemistry.chemical_compound Superoxides law Psoriasis Humans Medicine Hydrogen peroxide Opsonin Peroxidase Chemiluminescence business.industry Superoxide Myeloperoxidase activity Hydrogen Peroxide Middle Aged medicine.disease Peripheral blood chemistry Luminescent Measurements Immunology business |
| Zdroj: | British Journal of Dermatology. 112:387-392 |
| ISSN: | 1365-2133 0007-0963 |
| DOI: | 10.1111/j.1365-2133.1985.tb02310.x |
| Popis: | We report an investigation of peripheral blood polymorphonuclear leukocytes (PMN) from untreated patients with mild, quiescent psoriasis. Four aspects of the 'metabolic burst' were measured to illustrate phagocytosis-related events. These were: myeloperoxidase activity, hydrogen peroxide release, superoxide production and luminol-amplified chemiluminescence. Our study does not support the concept of an intrinsic abnormality of the PMN in psoriasis, but provides additional evidence for disease activity-dependent changes in phagocytic behaviour. Possible interactions with certain humoral factors, the so-called opsonins, are discussed. |
| Databáze: | OpenAIRE |
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