A multi-laboratory investigation of drug background levels
| Autor: | Marcela N. Najarro, Edward Sisco |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Drug
Synthetic opioid Report writing Computer science media_common.quotation_subject 010401 analytical chemistry 01 natural sciences Data science 0104 chemical sciences Pathology and Forensic Medicine Analytical Chemistry 03 medical and health sciences 0302 clinical medicine Workflow Qualitative analysis Materials Chemistry Crime scene 030216 legal & forensic medicine Occupational exposure Physical and Theoretical Chemistry Drug identification Law Spectroscopy media_common |
| Zdroj: | Forensic chemistry (Amsterdam, Netherlands). 16 |
| ISSN: | 2468-1709 |
| Popis: | Identifying and quantifying the drug background in operational environments such as forensic laboratories is an emerging body of research. Knowing these levels is crucial to addressing issues like occupational exposure risk - due to the emergence of potent novel psychoactive substances and synthetic opioids - and data integrity - due to improvements in instrument sensitivity. The work presented here builds upon a prior study to provide a broader representation of the average drug background levels found on surfaces in forensic laboratories. Over 700 samples from 20 laboratories were collected, extracted, and analyzed quantitatively using LC-MS/MS, and qualitatively using TD-DART-MS. Quantitative analysis by LC-MS/MS included a panel of 18 drugs while the non-targeted qualitative analysis by TD-DART-MS screened for over three hundred drugs and excipients. The study focused primarily on surfaces within the drug unit and evidence receiving area of the laboratories, but also investigated other operational units (crime scene, drug interdiction, latent prints, and toxicology) as well as report writing. Background levels were highest within the drug unit of the laboratory, though detectable (tens of nanograms) levels were observed in nearly all sampled areas. The data from this expanded study plays a critical role in addressing laboratory concerns such as establishing drug identification reporting limits for new instrumentation and establishing new workflow or cleaning protocols while also providing a more comprehensive dataset for general environmental background studies. |
| Databáze: | OpenAIRE |
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