Ventricular Outflow Tract Obstruction Secondary to Leiomyosarcoma of the Right Ventricle
| Autor: | Jan Roelandts, Amir Shoja, Herve Deferm, Philip Claessens, Willem Willaert, Andre Heremans, Marc Vanderheyden |
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| Rok vydání: | 2001 |
| Předmět: |
Leiomyosarcoma
medicine.medical_specialty Heart disease Heart Ventricles Cardiac Neoplasm Ventricular outflow tract obstruction Ventricular Outflow Obstruction Heart Neoplasms medicine Atypia Humans Aged business.industry medicine.disease Magnetic Resonance Imaging Surgery body regions medicine.anatomical_structure Ventricle Immunohistochemistry Female Desmin medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Japanese Heart Journal. 42:377-386 |
| ISSN: | 1348-673X 0021-4868 |
| DOI: | 10.1536/jhj.42.377 |
| Popis: | Primary leiomyosarcomas of the heart, particularly those affecting the right ventricle, are uncommon. We report the case of a 70-year-old Belgian woman presenting with the symptoms of progressive exertional dyspnea and left-sided pleuritic pain. A leiomyosarcoma which originated from the right lateral ventricle wall, causing pulmonary outflow obstruction, was diagnosed. Pathology revealed a neoplasm with a myxoid stroma, high mitotic activity and nuclei expressing atypia. Immunohistochemical staining was positive for vimentine and desmin. Seven months after complete surgical resection the tumor relapsed. This case demonstrates the poor outcome, the high relapse rate and inefficiency of treatment associated with primary cardiac leiomyosarcomas. The current literature regarding the incidence, diagnostic techniques, treatment strategies and survival rates of this rare but terminal disease is reviewed. |
| Databáze: | OpenAIRE |
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