Ag@ZnO Nanoparticles Induce Antimicrobial Peptides and Promote Migration and Antibacterial Activity of Keratinocytes
| Autor: | Amrita Mishra, Rakesh Kumar Majhi, Soumitra Mohanty, Annelie Brauner, Md. Imran Khan |
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| Rok vydání: | 2021 |
| Předmět: |
Keratinocytes
Pore Forming Cytotoxic Proteins 0301 basic medicine Silver Letter 030106 microbiology Antimicrobial peptides Metal Nanoparticles wound healing medicine.disease_cause Silver nanoparticle Microbiology 03 medical and health sciences hBD2 RNase7 Extracellular medicine Humans innate immunity integumentary system Chemistry silver nanoparticle infection Anti-Bacterial Agents HaCaT 030104 developmental biology Infectious Diseases Staphylococcus aureus Zinc Oxide Antibacterial activity Wound healing Intracellular |
| Zdroj: | ACS Infectious Diseases |
| ISSN: | 2373-8227 |
| Popis: | Antibacterial activity of silver nanoparticles is often associated with toxicity to the host. We here report that noncytotoxic doses of silver nanoparticles coated with zinc oxide, Ag@ZnO, can stimulate proliferation and migration of human keratinocytes, HaCaT, with increased expression of Ki67 and vinculin at the leading edge of wounds. Interestingly, Ag@ZnO stimulates keratinocytes to produce the antimicrobial peptides hBD2 and RNase7, promoting antibacterial activity against both extracellular and intracellular Staphylococcus aureus isolated from wounds. Overall, these results suggest that Ag@ZnO has the potential to significantly improve treatment outcomes in clearing wound infection. |
| Databáze: | OpenAIRE |
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