HSF1-Activated Non-Coding Stress Response: Satellite lncRNAs and Beyond, an Emerging Story with a Complex Scenario
| Autor: | Claire Vourc’h, Solenne Dufour, Kalina Timcheva, Daphné Seigneurin-Berny, André Verdel |
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| Přispěvatelé: | seigneurin-berny, Daphne, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA) |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
RNA-POLYMERASE-II
NEAT1 eRNA HSF1 lncRNA Heat Shock Transcription Factors [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN] Genetics Animals SATIII B2 RNA TERRA TRANSCRIPTION Genetics (clinical) Genetics & Heredity Mammals Science & Technology fungi TERRA HEAT-SHOCK FACTOR-1 DNA CONSENSUS SEQUENCE SINE TRANSPOSABLE ELEMENTS [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN] REGULATED TRANSCRIPTION RNA Long Noncoding REPEAT-CONTAINING RNA PERICENTRIC HETEROCHROMATIN EMBRYONIC STEM-CELLS Life Sciences & Biomedicine Heat-Shock Response Transcription Factors |
| Zdroj: | Genes Genes, 2022, 13 (4), pp.597. ⟨10.3390/genes13040597⟩ |
| ISSN: | 2073-4425 |
| DOI: | 10.3390/genes13040597⟩ |
| Popis: | In eukaryotes, the heat shock response is orchestrated by a transcription factor named Heat Shock Factor 1 (HSF1). HSF1 is mostly characterized for its role in activating the expression of a repertoire of protein-coding genes, including the heat shock protein (HSP) genes. Remarkably, a growing set of reports indicate that, upon heat shock, HSF1 also targets various non-coding regions of the genome. Focusing primarily on mammals, this review aims at reporting the identity of the non-coding genomic sites directly bound by HSF1, and at describing the molecular function of the long non-coding RNAs (lncRNAs) produced in response to HSF1 binding. The described non-coding genomic targets of HSF1 are pericentric Satellite DNA repeats, (sub)telomeric DNA repeats, Short Interspersed Nuclear Element (SINE) repeats, transcriptionally active enhancers and the NEAT1 gene. This diverse set of non-coding genomic sites, which already appears to be an integral part of the cellular response to stress, may only represent the first of many. Thus, the study of the evolutionary conserved heat stress response has the potential to emerge as a powerful cellular context to study lncRNAs, produced from repeated or unique DNA regions, with a regulatory function that is often well-documented but a mode of action that remains largely unknown. ispartof: GENES vol:13 issue:4 ispartof: location:Switzerland status: published |
| Databáze: | OpenAIRE |
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